Titlebook: Genomic Imprinting; An Interdisciplinary Rolf Ohlsson Book 1999 Springer-Verlag Berlin Heidelberg 1999 Activation.biology.cancer.chromosome

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The Mechanisms of Genomic Imprinting,erefore, to invoke fundamentally novel mechanisms to explain the imprinting phenomenon in mammals. For example, the different factors involved in imprinting, such as the stable propagation of different chromatin states that repress or permit gene transcription, are well-known entities in a wide rang

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Mechanisms of Transcriptional Regulation,c expression of certain genes. The assumption has been, therefore, that the transcriptional regulatory systems of imprinted genes would directly or indirectly represent the principal focus of the imprinting process. As this chapter will discuss, however, our perceptions of gene regulation mechanisms

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Epigenetic Control of Gene Expression,c signal, leading to the establishment of a heritable but potentially reversible inactive conformation of the gene. A large body of experimental data, that has been accumulated in the last two decades or so, clearly indicates that epigenetic control of gene expression in mammals is achieved by DNA m

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Polycomb Silencing and the Maintenance of Stable Chromatin States,e expression essential for the patterning, morphogenesis and allocation of cellular identities in different parts of the embryo. These patterns are produced by the interaction of multiple transcription factors, repressor and activators present in different parts of the embryo or induced by diffusibl

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Allelic ,-sensing and Imprinting,ccur in a balanced way. Interactions between homologous loci has been shown to occur in somatic cells of plants and animals. In general, somatic pairing is less extensive than in the germ cells. Although their functional significance remains unclear, recent observations show that homologous interact

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