Titlebook: Genomic Applications in Pathology; George Jabboure Netto,Karen L. Kaul Book 2019Latest edition Springer International Publishing AG, part

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Dimensions of Development Theory,nges facing the development of new sequencing technologies. This chapter provides a broad overview of emerging new sequencing technologies including single-molecule and nanopore approaches. Potential applications in nucleic acid analysis which will be enabled by these technological advances are also highlighted.

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https://doi.org/10.1007/978-3-642-13153-0r different preparations of biological samples, taking into account advantages and disadvantages of each approach. Furthermore, we discuss the diagnostic and therapeutic efficacy of miRNAs as well as their future roles in personalized medicine, from a technical perspective.

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Clinical Implementation of Next-Generation Sequencing (NGS) Assays clinicians. Guideline documents now exist, and many laboratories have already successfully applied the existing clinical laboratory regulations to this novel category of high-complexity testing. Nevertheless, NGS technologies hold great promise for the future despite some currently perceived barriers to implementation.

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Ethical Issues in Clinical Genetics and Genomicsso do not provide powerful information about many disease-linked variants. It ends by discussing how WGS and other “broad” tests will greatly exacerbate the ethical and legal problems of existing testing methods, particularly with respect to accuracy, conveying results, and confidentiality.

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