Titlebook: Genome Instability in Cancer Development; Nathan Back,Irun R. Cohen,Erich A. Nigg Book 2005 The Editor(s) (if applicable) and The Author(s

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The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature B.V. 200

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Genome Instability in Cancer Development978-1-4020-3764-1Series ISSN 0065-2598 Series E-ISSN 2214-8019

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,Einführung in die Fachsprache Medizin,e NER factors and global genome repair defects translates into a complex and highly pleiotropic set of syndromes. However, by careful analysis of patients and mouse mutants we can come to the following simplifications. A defect in the global genome subpathway of NER, as observed in XPC patients, cau

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Sprache und Sprachgebrauch untersuchen,me is to segregate equally in mitosis for a healthy life of the host”. Chromosomes are equipped with the kinetochore, a critical control centre to regulate their movement as well as cell cycle progression. Recent advance in biochemical technology has greatly contributed to the identification of nove

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Die Erwerbung von Deutsch-Ostafrika,p53, ATM, BRCA1, NBS1, Mre11 and Chk2, underlining the critical role of the DNA damage response pathway in tumour suppression. The elucidation of the DNA damage response pathway will not only help us understand the mechanism of tumour suppression, but also allow for the discovery of new drug targets

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https://doi.org/10.1007/1-4020-3764-3Chromosom; DNA; Telomere; aging; dynamics; genes

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0065-2598 ecular analysis of one of the most fundamental traits of humResearch over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tu

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Book 2005rangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of ant

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