| 书目名称 | Genome Instability in Cancer Development |
| 编辑 | Nathan Back,Irun R. Cohen,Erich A. Nigg |
| 视频video | |
| 概述 | A focus on genome instability – a hallmark of human cancer.An in-depth discussion of the causes and consequences of genome instability.A molecular analysis of one of the most fundamental traits of hum |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that “cancer” is an extraordinarily complex disease: although some cancers of the haematopoietic system show only a limited number of characteristic chromosomal aberrations, most solid tumours display a myriad of genetic changes and considerable genetic heterogeneity. This is thought to reflect a trait commonly referred to as ‘genome instability’, so that no two cancers are ever likely to display the exact same genetic alterations. Numerical and structural chromosome aberratio |
| 出版日期 | Book 2005 |
| 关键词 | Chromosom; DNA; Telomere; aging; dynamics; genes |
| 版次 | 1 |
| doi | https://doi.org/10.1007/1-4020-3764-3 |
| isbn_ebook | 978-1-4020-3764-1Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature B.V. 200 |
发表于 2025-3-21 19:35:11
