Titlebook: Genome Editing in Animals; Methods and Protocol Izuho Hatada Book 2017 Springer Science+Business Media LLC 2017 enzymes.TALEN.ZFN.CRISPR.ze

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Vincent C. S. Wiers,A. (Ton) G. de Kokcurrently possible using genome editing techniques incorporating zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), or clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9. Genome-edited animals have been produced by the introduction of endonucleas

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,Das Präsidium des Rat Für Formgebung,ecause of their anatomical and physiological similarity to humans. The recent development of genome editing techniques, such as ZFN, TALEN, and CRISPR/Cas9, has rapidly expanded the use of genome editing tools in a variety of animals, resulting in the relatively easy and efficient generation of gene

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Vanessa L. Peters,James D. Slottan resulting in a frameshift-mediated target gene disruption. It remains difficult to perform targeted integration of exogenous genes by genome editing technologies. DSBs can be restored through DNA repair mechanisms, such as non-homologous end joining (NHEJ), microhomology-mediated end joining (MMEJ

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