Titlebook: Genome Editing; The Next Step in Gen Toni Cathomen,Matthew Hirsch,Matthew Porteus Book 2016 The Editor(s) (if applicable) and The Author(s)

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Electromechanical Control Using the Arduinoar pluripotency, and the ability to precisely manipulate the genome with engineered nucleases. Together, these two advances have significant potential in the development of the next generation of cell and gene therapies. This review will discuss human and animal models of stem cells and the applicat

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The Development and Use of Zinc-Finger Nucleases,bly effective, enhancing the frequency of gene targeting several orders of magnitude. The modularity of DNA recognition by zinc fingers has made it possible to design ZFNs for a wide range of genomic targets in a remarkable assortment of organisms and cell types. Use of this platform helped define t

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Genome Editing by Aptamer-Guided Gene Targeting (AGT), only recently been applied to gene correction. The effectiveness of using aptamers for gene targeting comes from their versatility, as aptamers can be used in conjunction with currently existing genome modification systems. Here we describe how DNA aptamers can be exploited to increase donor DNA av

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Stimulation of AAV Gene Editing via DSB Repair,relevant for disease therapy. In fact, zinc-finger nucleases (ZFNs) that induce deletions in the HIV CCR5 receptor in patient T cells ex vivo have demonstrated promise upon treated cell infusion in the clinic. In these applications, adenoviral delivery vectors were employed however; there is growing