Titlebook: Genetics and Product Formation in Streptomyces; Book 1991

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Introduction formation of chains of uninucleoidal spores from specialized aerial hyphae. The formation of aerial hyphae often coincides with antibiotic production and the occurrence of various pleiotropic mutants defective in both processes shows that the study of morphological differentiation may prove relevan

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Gene Expression during Sporulation in , A3(2)nd functionally distinct regions (reviewed by Chater, 1989a). The tips of hyphae growing out into the agar convert surrounding nutrients into biomass, whereas hyphae in the central region of the colony often show extensive lysis (Wildermuth, 1970), perhaps connected with the supply of their contents

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Measurement of Translational Accuracy in ,oth the types of cells the natural level of translational accuracy achieved is far from its attainable maximum since it can be increased by mutations affecting mostly ribosomal proteins. This indicates that a certain optimal level of translational fidelity was selected during evolution rather than i

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Antibiotic Biosynthesisearly 1980’s (e.g. 1,2) was followed by the cloning of complete pathways (e.g. 3,4). Without exception, antibiotic production genes in streptomycetes are clustered on the chromosome. Often a resistance genes (or genes) is also located within the cluster (e.g. 5,6) which provides a facile strategy fo

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Cephamycin Production by ,in (penicillin G) and phenoxymethylpenicillin (penicillin V), contain non-polar side chains, e.g. phenylacetate and phenoxyacetate, respectively, and are made only by filamentous fungi; the best known of these is .. The hydrophilic types are penicillin N, cephalosporins and 7-a-methoxycephalosporins

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