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Titlebook: Genetic Studies in Model Organisms; From Classical to Mo Kwang-Wook Choi Book 2024 The Editor(s) (if applicable) and The Author(s), under e

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https://doi.org/10.1007/978-1-4842-6137-8 from altered mutant phenotypes in genetic model organisms. Phenotypes are expressed mainly by loss-of-function mutations. However, loss-of-function mutations can often be compensated by the function of related genes or parallel pathways, causing hurdles in gene function studies. In such cases, gain
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Decoding Digital Consumer Behaviort developmental processes, causing lethality. Analysis of lethal mutations is complicated since homozygous mutants die during development. This chapter discusses making genetic mosaics to study the function of such essential genes. The mosaic analysis is invaluable for analyzing the function of esse
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Terufumi Fujiwara,Eugenia Chiappe changes in DNA. Such epigenetic phenomena play increasingly critical roles in regulating gene expression in most cellular and developmental events. This chapter focuses on the genetic identification of epigenetic regulators of gene expression. Position-effect variegation (PEV) is a well-known epige
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Critical Approaches to Purchased Advertisingay essential roles in translational processes. In addition, various long and small non-coding RNAs have been discovered. For example, small interfering RNAs and microRNAs regulate genes by posttranscriptional gene silencing. This chapter focuses on a class of small non-coding RNA called Piwi RNA (pi
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es have only one X chromosome instead of two in females. The X chromosome dosage difference must be compensated for the development and survival of animals. This chapter discusses distinct dosage compensation mechanisms in three model systems. Firstly, we will begin with Mary Lyon’s hypothesis that
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Solutions for the Equation of Motion,ll death or apoptosis is required as a normal process for proper development or occurs in response to various harmful stimuli. Thus, genetic regulation of programmed cell death is essential in diverse biological processes and diseases, including cancer. This chapter focuses on genetic studies of cel
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