Titlebook: Genetic Diversity of RNA Viruses; John J. Holland (Professor of Biology and Molecula Book 1992 The Editor(s) (if applicable) and The Autho

instill

Book 1992nd mouth disease viruses, and Newcastle disease virus. During the past decade, it has become clear that most, it not all. , RNA viruses (riboviruses and retroviruses) are much more mutable than was recognized previously, and that this great mutability generates extremely complex populations consisti

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https://doi.org/10.1007/978-3-663-13664-4ating new organisms best able to survive in the environment that surrounds them. Survival within an exceptionally hostile environment might be favored by populations containing a wide spectrum of pre-existing mutants that provide a diverse repertoire for selection.

occurrence

RNA Virus Populations as Quasispecies,viruses. For example, the mutation rate of bacteriophage T4 approximates 10. per base pair per replication (. 1969). However, some DNA viruses may avoid high-fidelity replication mechanisms (. et al. 1969; . et al. 1984) to gain the evolutionary advantages of high mutation frequencies (. and . 1987).

lipids

Selection of Zidovudine-Resistant Variants of Human Immunodeficiency Virus by Therapy,apy in humans has selected for drug-resistant variants of influenza A virus, herpes simplex virus, varicella zoster virus, cytomegalovirus and rhinovirus (. 1990). The prospect of drug resistance to zidovudine (AZT) therefore did not appear as a surprise to many.

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