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Titlebook: Genetic Diversity of RNA Viruses; John J. Holland (Professor of Biology and Molecula Book 1992 The Editor(s) (if applicable) and The Autho

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书目名称Genetic Diversity of RNA Viruses
编辑John J. Holland (Professor of Biology and Molecula
视频video
丛书名称Current Topics in Microbiology and Immunology
图书封面Titlebook: Genetic Diversity of RNA Viruses;  John J. Holland (Professor of Biology and Molecula Book 1992 The Editor(s) (if applicable) and The Autho
描述Many RNA viruses have been known for decades to be genetically and biologically quite variable. Some well-known examples are influenza viruses, foot and mouth disease viruses, and Newcastle disease virus. During the past decade, it has become clear that most, it not all. , RNA viruses (riboviruses and retroviruses) are much more mutable than was recognized previously, and that this great mutability generates extremely complex populations consisting of indeterminate mixtures of related variants (Le. , "mutant swarms" or "quasispecies" populations). This is also true of DNA viruses (such as hepatitis DNA genomes via RNA transcripts B virus) which replicate their that are reverse-transcribed back to DNA. This hypermutability of RNA replicons provides great biological adaptability for RNA virus genomes. It also allows (but does not necessitate) RNA viruses, so that they can extremely rapid evolution of evolve over a million times more quickly than their eukaryotic DNA-based hosts. The genetics of RNA replicons is so unusual (and often counterintuitive) that it has many important biological conse­ quences which are neither readily apparent nor widely under­ stood. Failure to understand
出版日期Book 1992
关键词AIDS; Antigen; Evolution; Mutation; RNA-Viren; Riboviruses; Virologie; Viruses; antiviral drug resistance; re
版次1
doihttps://doi.org/10.1007/978-3-642-77011-1
isbn_softcover978-3-642-77013-5
isbn_ebook978-3-642-77011-1Series ISSN 0070-217X Series E-ISSN 2196-9965
issn_series 0070-217X
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
The information of publication is updating

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https://doi.org/10.1007/978-3-642-50857-8NA seen in viruses containing segmented genomes. The mechanism of RNA recombination appears to be similar to the generation of defective interfering (DI) RNA, since they both involve polymerase jumping during RNA synthesis. However, unlike the production of DI RNA, which is a relatively common pheno
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Inga Ellen Kastens,Peter G. C. Lux. and . 1988). The original theoretical concept of . and colleagues concerned populations of infinite numbers of individual molecules and ideal, steady-state equilibrium conditions (recent review on the theoretical concept in . et al. 1989). It is clear that in spite of their large population size,
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,Außenhandels-Repetitorium in Kurzform,te of genetic variation of the viruses only started in the 1980s. Recent studies have revealed that like other RNA viruses, polioviruses show typical features of a quasispecies with a multitude of variants present in a host at a given time and drifts in the composition of the mixture in relation to
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Vom Autismus in Behandlung und Vorbeugung,; . and . 1987). Antiviral activity has been demonstrated in various animal models of influenza (. 1986) and during clinical use in humans (. 1990). Amantadine- and rimantadine-resistant mutants have been recovered during studies in mice (. et al. 1970, . and . 1972), birds (. et al. 1985; . et al.
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