书目名称 | Genetic Diversity of RNA Viruses |
编辑 | John J. Holland (Professor of Biology and Molecula |
视频video | |
丛书名称 | Current Topics in Microbiology and Immunology |
图书封面 |  |
描述 | Many RNA viruses have been known for decades to be genetically and biologically quite variable. Some well-known examples are influenza viruses, foot and mouth disease viruses, and Newcastle disease virus. During the past decade, it has become clear that most, it not all. , RNA viruses (riboviruses and retroviruses) are much more mutable than was recognized previously, and that this great mutability generates extremely complex populations consisting of indeterminate mixtures of related variants (Le. , "mutant swarms" or "quasispecies" populations). This is also true of DNA viruses (such as hepatitis DNA genomes via RNA transcripts B virus) which replicate their that are reverse-transcribed back to DNA. This hypermutability of RNA replicons provides great biological adaptability for RNA virus genomes. It also allows (but does not necessitate) RNA viruses, so that they can extremely rapid evolution of evolve over a million times more quickly than their eukaryotic DNA-based hosts. The genetics of RNA replicons is so unusual (and often counterintuitive) that it has many important biological conse quences which are neither readily apparent nor widely under stood. Failure to understand |
出版日期 | Book 1992 |
关键词 | AIDS; Antigen; Evolution; Mutation; RNA-Viren; Riboviruses; Virologie; Viruses; antiviral drug resistance; re |
版次 | 1 |
doi | https://doi.org/10.1007/978-3-642-77011-1 |
isbn_softcover | 978-3-642-77013-5 |
isbn_ebook | 978-3-642-77011-1Series ISSN 0070-217X Series E-ISSN 2196-9965 |
issn_series | 0070-217X |
copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |