Titlebook: Genes, Development and Cancer; The Life and Work of Howard D. Lipshitz (Senior Scientist and Head, Pro Book 2004 Kluwer Academic Publishers

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Lewis and the Genetic Control of Developmentsiologist is concerned with processes going on in the cell, but has no means of finding out at present how far the chromosomes may or may not have affected the process. He is, however, as a rule sufficiently broad-minded to concede at least that any change in the complex of factors present in a cell

BILL

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LURE

E. B. Lewis and His Science second half of the nineteenth century. These converged a century later to provide deep insights into the mechanistic basis of animal development, how genes control developmental processes, and the evolutionary origins of the metazoan body plan. This convergence was brought about, in no small part,

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Lewis and the Nature of the Geneapping by meiotic recombination, discovery of rearranged chromosomes, proof that ionizing radiation causes mutations, discovery and mapping of salivary gland polytene chromosomes, and the cytogenetic mapping of chromosomal rearrangements on these chromosomes (reviewed in Sturtevant, 1965).

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Star-Recessive, A Spontaneous Mutation in ,larity in the arrangement of eye facets and facet hairs, the homozygote being lethal), a number of flies appeared with small narrow eyes. When these were mated ., all of the F. had abnormal eyes, but these varied in size from that of S/+ (see Table IV) to a narrow slit of red pigment on which only a

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NEG

The Relation of Repeats to Position Effect in ,menon of position effect has been given by Sturtevant (1925), Dubinin and Sidorow (1935), and Panshin (1935). Position effects have been detected only in cases in which the relative position of a gene with respect to its neighbors has been altered by a chromosomal rearrangement. It is conceivable th

DEBT

The Pseudoallelism of White and Apricot in ,es, namely, that it is made up of “pseudoalleles,” or closely linked genes with similar effects, has usually been considered ruled out by two kinds of evidence. In the first place early attempts to resolve the series by crossing over failed in spite of numerous tests involving most of the mutants av