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Titlebook: Gene Transfer and Therapy in the Nervous System; Fred H. Gage,Yves Christen Conference proceedings 1992 Springer-Verlag Berlin Heidelberg

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Delivery of Nerve Growth Factor Within the Rat Brain Using Genetically Modified Cells, system. Intracerebral grafts of nerve growth factor-producing fibroblasts have been used to assess the regenerative capacities of select neuronal populations within the damaged adult rat brain. Our data reveal that this trophic factor is a necessary requirement to sustain neurons following axotomy.
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Phenotypic Plasticity and Neural Grafting, to replace in the host. For this purpose, fetal neurons of the same type or suitable neuronal cell lines are often used. Two other possibilities are discussed here. First, adrenal chromaffin cells are a source of multipotential progenitor cells capable of generating a variety of neuronal phenotypes
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The Sympathoadrenal Progenitor of the Neural Crest: Basic Biology and Therapeutic Potential, neural progenitor cells. The sympathoadrenal (SA) progenitor of the peripheral nervous system is among the best-characterized of such progenitors, in vertebrates. This cell, which derives from the neural crest, has a restricted developmental program that allows it to develop into a chromaffin cell
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Gene Transfer into the Nervous System using Recombinant Herpes Virus Vectors,stranded DNA virus has a large genome (150 kb) which may carry up to 50 kb of foreign DNA at replaceable sites. This virus has a number of advantages for delivery of genes to neurons. It can be taken up by nerve terminals and transported by rapid retrograde transport to the cell nucleus; it can be p
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