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Titlebook: Gene Transfer and Therapy in the Nervous System; Fred H. Gage,Yves Christen Conference proceedings 1992 Springer-Verlag Berlin Heidelberg

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Delivery of Nerve Growth Factor Within the Rat Brain Using Genetically Modified Cells, As importantly, nerve growth factor is needed to induce and promote the regeneration of lesioned axons. Regardless of the cellular or extracellular substrates used by these regrowing axons, the availability of nerve growth factor is a minimum requirement for successful regeneration of adult perturbed axons.
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Clinical Aspects of Electroporationuscle cytoskeletal protein (Koenig et al. 1988). Dystrophin protein (Hoffmann et al. 1988) and transcript (Oronzi Scott et al. 1988) are either absent or severely deficient in DMD patients (Koenig et al. 1988).
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Clinical Aspects of Neutron Capture Therapyation of transgenic mice bearing a high-copy number of the NF-L gene revealed the existence of a translational control impeding overexpression of NF-L in CNS neurons. Unlike the NF-L gene, overexpression of the human NF-H gene in transgenic mice was not impeded by the existence of such posttranscriptional controls.
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Phenotypic Plasticity and Neural Grafting,host environment to provide the instructive cues necessary to promote the differentiation of phenotypes suitable for the host circuitry. If the latter paradigm proves efficacious, such grafts could serve as bioassays for instructive factors ..
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Lineage, Migration, and Phenotype in Avian Optic Tectum: Analysis with Recombinant Retroviral Vectoand a potentially bioactive gene, or its antisense copy, in clones of cells. In initial studies, overexpression of an oncogene (v-src) and antisense suppression of an adhesion molecule (integrin β1) have perturbed the behavior of lacZ-positive cells in ways that provide insights into the functions of these genes.
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Signal-averaged surface electrocardiography, olfactory bulb after intranasal inoculation (Dobson et al. 1989). Focal infection of specific brain regions can be achieved by stereotactic injection of small volumes of virus into defined brain regions (McFarland et al. 1986; Bak et al. 1977).
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Development of Herpes Simplex Virus as a Gene Transfer Vector for the Central Nervous System, olfactory bulb after intranasal inoculation (Dobson et al. 1989). Focal infection of specific brain regions can be achieved by stereotactic injection of small volumes of virus into defined brain regions (McFarland et al. 1986; Bak et al. 1977).
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