书目名称 | Gene Therapy of Cancer | 副标题 | Methods and Protocol | 编辑 | Wolfgang Walther,Ulrike Stein | 视频video | | 概述 | Includes supplementary material: | 丛书名称 | Methods in Molecular Medicine | 图书封面 |  | 描述 | Since the discovery of the molecular structure of genes and the unveiling of the molecular basis of numerous human diseases, scientists have been fas- nated with the possibility of treating certain diseases by transducing foreign DNA into the affected cells. Initially, it was proposed that the foreign DNA could either replace defective nonfunctional genes, or code for therapeutic proteins. This concept has evolved into the rapidly growing field of gene therapy. Even though surgery, radiotherapy, and chemotherapy are widely ava- able and routinely used for cancer treatment, these therapies fail to cure approximately 50 percent of cancer patients. Therefore, since it is a disease characterized by aberrant gene expression, cancer has been a target of gene therapy research since the inception of this treatment modality. Numerous cancer gene therapy strategies are currently being investigated, including gene replacement therapy, the regulation of gene expression to modulate immu- logical responses to tumors, the direct killing of tumor cells, and direct int- ference with tumor growth. In this context, gene transfer systems, tumor-specific expression vectors, and novel therapeutic genes | 出版日期 | Book 20001st edition | 版次 | 1 | doi | https://doi.org/10.1385/1592590861 | isbn_softcover | 978-0-89603-843-1 | isbn_ebook | 978-1-59259-086-5Series ISSN 1543-1894 Series E-ISSN 1940-6037 | issn_series | 1543-1894 | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
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