Titlebook: Gene Therapy; R. E. Sobol,K. J. Scanlon,E. Nestaas Conference proceedings 1998 Springer-Verlag Berlin Heidelberg 1998 Expression.Gentherap

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https://doi.org/10.1057/9781137313362process of genetic alterations of oncogenes and/or tumor suppressor genes (Foulds 1958; Fearon and Vogelstein 1990). Small molecules interfering with genetic deregulation might become key players in the future search for new anti—cancer drugs. Examples of such molecules include antisense oligonucleo

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https://doi.org/10.1057/9780230374591njection of a gene therapeutic curing familial hypercholesterolemia, correcting severe combined immunodeficiency, removing the death sentence from those with a hereditary colon cancer gene, or growing new blood vessels to relieve chronic myocardial ischemia. The last decade has seen much progress to

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https://doi.org/10.1007/978-1-137-07379-2some instances may be overcome by the use of higher doses (Hryniuk and Bush 1984). Currently available chemotherapy, however, is often associated with various toxicities, in particular, bone marrow toxicity which is limiting for many of these agents. Use of recombinant hematopoietic growth factors o

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