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Titlebook: Gene Delivery to Mammalian Cells; Volume 1: Nonviral G William C. Heiser Book 2004 Humana Press 2004 DNA.Ethylen.Vivo.gene transfer.genes.l

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Delivery of Transposon DNA to Lungs of Mice Using Polyethyleneimine-DNA Complexesand polycations (.,.) have all been reported as effective methods for intravascular gene delivery to the lung. Of the different nonviral approaches, DNA complexes with polyethyleneimine (PEI) have been reported to provide the most effective gene delivery to the lung.
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M. Claire Greene,Jeremy C. Kane vectors has been directed toward a therapy for cystic fibrosis (.-.), other lung diseases, including asthma, chronic obstructive pulmonary disease, and cancer are being explored as viable disease targets.
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https://doi.org/10.1057/9781137280671monstrated to react spontaneously with anionic DNA to form lipid-DNA complexes, or “lipoplexes” (.). These lipoplexes demonstrated effective binding to cells in vitro and facilitation of intracellular delivery of a transgene. Felgner provides a detailed history of the progress leading up to and including lipofection (.).
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Permanent Versus Temporary ENS,ood flow through the pulmonary capillaries is slow and discontinuous. On inspiration, as the alveoli fill with air, blood flow slows and stops. On expiration, blood flow resumes. Slower blood flow in the lung favors DNA binding to the endothelial cells.
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