Titlebook: Gadd45 Stress Sensor Genes; Dan A. Liebermann,Barbara Hoffman Book 20131st edition The Editor(s) (if applicable) and The Author(s), under

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Gadd45 Proteins in Immunity,of granulocytes and macrophages. Moreover, Gadd45β regulates autophagy, a catabolic pathway that also degrades intracellular pathogens. Regarding adaptive immunity, Gadd45 proteins are especially well characterized in T cells. For instance, Gadd45β and Gadd45γ regulate cytokine expression and Th1 di

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Gadd45 in the Liver: Signal Transduction and Transcriptional Mechanisms,inds to CAR and activates its transcriptional stimulation. Thus, Gadd45β protects the liver through two entirely different processes: binding MKK7 to block damaging signal transduction or binding CAR to coactivate anabolic transcription.

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Gadd45 Proteins: Key Players of Repair-Mediated DNA Demethylation,ifferentiation cues. They are well-characterized regulators of cell cycle, senescence, survival, and apoptosis. More recently, it has become clear that Gadd45 proteins promote active DNA demethylation thereby mediating gene activation. This epigenetic function of Gadd45 is important for differentiat

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Gadd45 Stress Sensors in Preeclampsia,, inflammatory cytokines, and oxidative stress were reported as contributing factors to the preeclamptic pathology. Seeking common sensors of various stressors in preeclampsia is of new interest and can potentially benefit in disease prevention and treatment. Recent studies have highlighted the role