| 书目名称 | Gadd45 Stress Sensor Genes | | 编辑 | Dan A. Liebermann,Barbara Hoffman | | 视频video | | | 概述 | Provides a comprehensive picture of the unique global role Gadd45 genes play as stress sensors and the molecular pathways involved.The functions of Gadd45 proteins are mediated by protein-protein inte | | 丛书名称 | Advances in Experimental Medicine and Biology | | 图书封面 |  | | 描述 | Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this boo | | 出版日期 | Book 20131st edition | | 关键词 | gadd45 genes; gene function; proteins; stress sensors; stress signaling | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4614-8289-5 | | isbn_softcover | 978-1-4939-5390-5 | | isbn_ebook | 978-1-4614-8289-5Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
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发表于 2025-3-21 17:50:27
