Titlebook: GTPase Protocols; The Ras Superfamily Ed Manser,Thomas Leung Book 2002 Humana Press 2002

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*Non-Euclidean (Hyperbolic) Geometry,ses are further regulated by guanine-nucleotide dissociation inhibitors (GDIs), which can inhibit both the exchange of GTP and the hydrolysis of bound GTP. Rho GDIs, as well as members of the ERM family (ezrin, radixin, and moesin), also appear to play a crucial role in the translocation of Rho-like

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Robyn Klingler-Vidra,Yu Ching Kuois coupled to the delivery of a Rab GTPase to a specific membrane compartment (.,.); the Rab GTPase is subsequently converted to the GTP-bound form by the action of a GEP. The GTP-bound form then interacts with a downstream effector(s). Thereafter, the GTP-bound form is converted to the GDP-bound fo

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Eric Hershberg,William M. LeoGrandend to function as regulators of membrane traffic and the actin cytoskeleton (.–.). In biochemical studies, Arfs have also been found to activate phospholipase D (PLD) and phosphatidylinositol 4-phosphate 5-kinase, and to bind to several putative effectors such as arfaptin, arfophilin, and the GGAs (

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https://doi.org/10.1007/978-3-030-20675-8R) and Golgi complex and in the maintenance of the organization of the Golgi complex (.). Arf1 serves this dual function through the modification of Golgi-membrane lipid composition and the assembly of cytosolic coat-protein complexes onto Golgi membranes.

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Preparation of GTPases for Structural and Biophysical Analysisentiation and proliferation, membrane trafficking, and nuclear import and export. Based on sequence homology, this superfamily can be divided into the Ras, Rho, Ran, Arf, Rab, and Rad subfamilies, which all have distinct biological activities. All members of this superfamily act as molecular switche