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Titlebook: GTPase Protocols; The Ras Superfamily Ed Manser,Thomas Leung Book 2002 Humana Press 2002

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发表于 2025-3-21 17:44:40 | 显示全部楼层 |阅读模式
书目名称GTPase Protocols
副标题The Ras Superfamily
编辑Ed Manser,Thomas Leung
视频video
概述Includes supplementary material:
丛书名称Methods in Molecular Biology
图书封面Titlebook: GTPase Protocols; The Ras Superfamily Ed Manser,Thomas Leung Book 2002 Humana Press 2002
描述In the last 10 years researchers have firmly established key roles for R- related GTPases in almost every aspect of cell biology. In the 1980s the pro- oncogene Ras itself was the focus of interest, though in the 1990s this shifted to the increasing variety of Ras-related proteins. In this new decade much yet needs to be done to establish the role for all the small GTPases now uncovered by the human genome project. In particular, these GTPases need to be und- stood in the appropriate biochemical and cellular contexts. In the process of trying to uncover the role of these versatile proteins, a variety of novel te- niques and methodologies has been developed. These now enable investi- tors to move easily within a diversity of fields ranging from structural studies to real-time in vivo analysis of a GTPase. In recognition of the need for access to key background methodologies, GTPase Protocols: The Ras Superfamily is devoted to techniques that are pr- ently widely used and that will continue to be the standard for researchers worldwide. Each chapter is aimed at supplying detailed methodologies to allow reproduction in any laboratory, while also providing the general pr- ciples on whic
出版日期Book 2002
版次1
doihttps://doi.org/10.1385/1592592813
isbn_softcover978-1-61737-261-2
isbn_ebook978-1-59259-281-4Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightHumana Press 2002
The information of publication is updating

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Yoshinori Hara,Senko Ikenobo,Spring H. Hane are the organization and dynamics of the actin cytoskeleton, intercellular and cell-substrate adhesion, vesicle trafficking, and lipid metabolism (.). Recently, Rac has been shown to stimulate the transcription of collagenase-1, a metalloproteinase involved in the remodeling of extracellular matrix (.).
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Effects of Rho Family GTPases on Cell-Cell Adhesion, which in turn is linked to the actin cytoskeleton via α-catenin. This linkage between cadherins and the actin cytoskeleton is required for the development of a strong adhesive state (.). However, the mechanism underlying the dynamic rearrangement in cell-cell adhesion remains unclear.
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French Unification Categorial Grammars,itogen activated protein kinase (MAPK) cascade. Constitutively activated, mutant forms of Ras such as RasV12 are found frequently in human tumors, and it is widely assumed that this oncogene acts via transcriptional activation of growth and proliferation pathways.
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Using cDNA-Representational Difference Analysis (cDNA-RDA) in Combination with Microarrays to Identiitogen activated protein kinase (MAPK) cascade. Constitutively activated, mutant forms of Ras such as RasV12 are found frequently in human tumors, and it is widely assumed that this oncogene acts via transcriptional activation of growth and proliferation pathways.
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