Titlebook: G Protein-Coupled Receptor Kinases; Vsevolod V. Gurevich,Eugenia V. Gurevich,John J.G. Book 2016 Springer Science+Business Media New York

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1557-2153 upled Receptor Kinases. features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies..978-1-4939-8142-7978-1-4939-3798-1Series ISSN 1557-2153 Series E-ISSN 1940-6053

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Canary

Differential Regulation of IGF-1 and Insulin Signaling by GRKsents of the GPCR system have been described for the insulin receptor (IR) and the insulin-like growth factor type 1 receptor (IGF-1R) and hence the rationale behind the development of a functional RTK/GPCR hybrid model. Given the IGF-1R’s important role in the development and maintenance of a malign

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Critical Role of GRK2 in the Prevention of Chronic Pain cAMP signaling to Epac/PKCε/ERK- mediated pathway. Via mechanisms that remain to be elucidated, low monocyte GRK2 leads to IL-10 deficiency and prolonged inflammatory pain. The clinical relevance of these findings is discussed in the light of the observed decrease of GRK2 in nociceptors, glia and l

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Mechanics

G-Protein-Coupled Receptors and Their Kinases in Cardiac Regulation, contractility, and blood pressure, in response to catecholamines and other neurohormones. For these reasons, GPCRs are dynamically regulated to prevent overstimulation that could lead to cardiac diseases like heart failure (HF). This dampening process, known as desensitization, is initiated throug

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Evolutionarily Conserved Role of G-Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathwaein kinase A, a key regulator of the Cubitus interruptus/GLI family transcription factors that mediate Hh transcriptional responses. This indirect role hints at a broader interconnectivity between GRKs, GPCR signaling, and Hh pathway function, an idea supported by the recent identification of severa