Titlebook: Excitatory Amino Acids; From Genes to Therap P. H. Seeburg,I. Bresink,L. Turski Conference proceedings 1998 Springer-Verlag Berlin Heidelbe

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Excitotoxicity, Genetics and Neurodegeneration in Amyotrophic Lateral Sclerosis,ly selective for upper motor neurones, a proportion of which are represented by Betz cells (Fig. lA) in the fifth layer of the motor cortex, and for lower motor neurones in the ventral horn of the spinal cord (Fig. 1B) and brainstem. The selective vulnerability of motor neurones in ALS is relative a

SEED

NO-NMDA Receptor Interactions: A Neuromolecular Approach to Novel Therapeutics, as an important mechanism for many cell types. For our purposes, we will confine our review of redox modulation to covalent modification of sulfhydryl (thiol) groups on protein cysteine residues. If they possess a sufficient redox potential, oxidizing agents can react to form adducts on single sulf

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Quantitative Estimation of NMDA Receptor-Mediated Ca2+ Entry in Central Neurons, and their high Ca. permeability, are utilized in a variety of complex physiological mechanisms. So far, NMDA receptor channels have been implicated in the regulation of activity-dependent neuronal development (Constantine-Paton 1990; McDonald and Johnston 1990), in triggering the formation of some

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https://doi.org/10.1007/978-3-642-90766-1eptors are designed for high Ca. permeability, and Ca. influx through the NMDA receptor channel is thought to be essential for activity-dependent synaptic modulation (reviewed in Bliss and Collingridge 1993). Furthermore, excessively high Ca. influx through NMDA receptors has pathophysiological cons

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Formen ambulanter Gruppentherapie usually dies from respiratory failure within 3–5 years from the onset of symptoms. One of the interesting clinical features in ALS is that certain groups of motor neurones tend to be selectively spared from injury, including those brainstem nuclei innervating extraocular muscles responsible for eye

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