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Titlebook: Excitatory Amino Acids; From Genes to Therap P. H. Seeburg,I. Bresink,L. Turski Conference proceedings 1998 Springer-Verlag Berlin Heidelbe

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,Ethnopoetik: Traum oder Möglichkeit?,-type] have been identified and classified according to their agonist selectivity, physiological properties and amino acid sequence homology between subunits constituting subtypes of these GluRs (reviewed by Seeburg 1993; Hollmann and Heinemann 1994). Several subunits have been discovered within eac
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Glutamate Receptor Channels, RNA Editing, and Epilepsy,eptors are designed for high Ca. permeability, and Ca. influx through the NMDA receptor channel is thought to be essential for activity-dependent synaptic modulation (reviewed in Bliss and Collingridge 1993). Furthermore, excessively high Ca. influx through NMDA receptors has pathophysiological cons
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Factors Regulating Excitotoxic Neurodegeneration: The Role of Calcium and the Mitochondria,ite 1990). Research from a number of laboratories has shown that the Ca permeability of ionotropic GluRs is subject to a number of control mechanisms which include the subunit composition of the receptor, editing of subunit specific mRNA, etc. Although the precise significance of all of these factor
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Excitotoxicity, Genetics and Neurodegeneration in Amyotrophic Lateral Sclerosis, usually dies from respiratory failure within 3–5 years from the onset of symptoms. One of the interesting clinical features in ALS is that certain groups of motor neurones tend to be selectively spared from injury, including those brainstem nuclei innervating extraocular muscles responsible for eye
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