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Titlebook: Excitatory Amino Acids; From Genes to Therap P. H. Seeburg,I. Bresink,L. Turski Conference proceedings 1998 Springer-Verlag Berlin Heidelbe

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书目名称Excitatory Amino Acids
副标题From Genes to Therap
编辑P. H. Seeburg,I. Bresink,L. Turski
视频video
丛书名称Ernst Schering Foundation Symposium Proceedings
图书封面Titlebook: Excitatory Amino Acids; From Genes to Therap P. H. Seeburg,I. Bresink,L. Turski Conference proceedings 1998 Springer-Verlag Berlin Heidelbe
描述In this book emerging questions of current glutamate research are addressed and new pathways which glutamte research may take in the future discussed. Since glutamate antagonists are still the major hope for the therapy of neurodegenerative disorders in humans, research activities dedicated towards the development of such novel drugs are the focus of public attention. The book comments on the most recent discoveries in the field of neuroprotection and neurodegeneration.
出版日期Conference proceedings 1998
关键词Glutamat; Molekulargenetik in der Neurologie; Neurobiologie; Neurodegenerative Krankheiten; RNA; antibody
版次1
doihttps://doi.org/10.1007/978-3-662-03596-2
isbn_softcover978-3-662-03598-6
isbn_ebook978-3-662-03596-2Series ISSN 0947-6075
issn_series 0947-6075
copyrightSpringer-Verlag Berlin Heidelberg 1998
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Glutamate in Neurodegenerative Disorders: Phenotype Resulting from Decreased Expression of AMPA Rechin this locus is controlled by posttranscriptional RNA editing (Sommer et al. 1991). Transgenic mice engineered to synthesize unedited GluR-B subunits express Ca.permeable AMPA receptors. These mice develop progressive neurodegeneration and spontaneous seizures (Brusa et al. 1995).
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Conference proceedings 1998 Since glutamate antagonists are still the major hope for the therapy of neurodegenerative disorders in humans, research activities dedicated towards the development of such novel drugs are the focus of public attention. The book comments on the most recent discoveries in the field of neuroprotectio
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0947-6075 discussed. Since glutamate antagonists are still the major hope for the therapy of neurodegenerative disorders in humans, research activities dedicated towards the development of such novel drugs are the focus of public attention. The book comments on the most recent discoveries in the field of neur
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Quantitative Estimation of NMDA Receptor-Mediated Ca2+ Entry in Central Neurons,forms of synaptic plasticity (Bliss and Collingridge 1993; Malenka and Nicoll 1993), as well as excitatotoxicity (Lipton 1993; Mody and MacDonald 1995) and programmed cell death (Bonfoco et al. 1995; Qin et al. 1996). Ca. entry through activated NMDA receptors has been suggested to be involved in the triggering of all of these processes.
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