Titlebook: Excitatory Amino Acids; From Genes to Therap P. H. Seeburg,I. Bresink,L. Turski Conference proceedings 1998 Springer-Verlag Berlin Heidelbe

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Friedens- und Konfliktforschung and their high Ca. permeability, are utilized in a variety of complex physiological mechanisms. So far, NMDA receptor channels have been implicated in the regulation of activity-dependent neuronal development (Constantine-Paton 1990; McDonald and Johnston 1990), in triggering the formation of some

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Hanns Ch. Heinrich,Ingo Langoschnt in processes as varied as the control of motor, cardiovascular and visual functions; synapse formation, stabilisation and elimination; learning and memory; and epilepsy, neuronal degenerative disorders and the mediation neuronal cell death (for recent reviews see Bliss and Collingridge 1993; Meld

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Conference proceedings 1998 Since glutamate antagonists are still the major hope for the therapy of neurodegenerative disorders in humans, research activities dedicated towards the development of such novel drugs are the focus of public attention. The book comments on the most recent discoveries in the field of neuroprotection and neurodegeneration.

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Excitatory Amino Acids978-3-662-03596-2Series ISSN 0947-6075

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Regulation of Glutamate Receptor Gene Expression in Global Ischemia,s such as synaptogenesis, formation of neuronal circuitry, and synaptic plasticity, including long-term potentiation and long-term depression. However, excessive activation of GluRs contributes to neurodegeneration following a wide range of neurological insults including ischemia, trauma, hypoglycem

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Factors Regulating Excitotoxic Neurodegeneration: The Role of Calcium and the Mitochondria,ion, we know that glutamate-mediated neurotransmission is mediated by a very large number of glutamate receptors (GluRs) which include families of both ionotropic (iGluRs) and metabotropic (mGluRs) receptors. Activation of these receptors can trigger several important phenomena. These include fast s