Titlebook: Excipient Applications in Formulation Design and Drug Delivery; Ajit S Narang,Sai H S. Boddu Book 2015 Springer International Publishing S

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Methoden der Diskontierung und Kalkulation,sessment by practitioners to avoid potential toxicity issues. Regulatory agencies in the United States of America and Europe are working together to create and maintain a database of Safety and Toxicity of Excipients for Pediatrics (STEP). The purpose of this book chapter is to review the role of ex

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Excipient Applications in Formulation Design and Drug Delivery,materials provide opportunities to design optimal drug delivery systems. Emerging trends in the design and development of drug products indicate ever greater need for characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents an integra

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Reactive Impurities in Excipientsr formation of potentially toxic degradants. The levels of reactive impurities in excipients may vary between lots and vendors. Screening of excipients for these impurities and a thorough understanding of their potential interaction with drug candidates during early formulation development can ensur

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Impact of Excipient Interactions on Solid Dosage Form Stabilitylowdown, or chemically by causing drug degradation. Recent research has allowed the distinction in chemical instability resulting from direct drug-excipient interactions and from drug interactions with excipient impurities. A review of chemical instability in solid dosage forms highlights common mec

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Protein—Surfactant Interactions at the Air-Water Interfaceurface characterization methods. A . ring geometry was utilized to quantify the elastic (Gʹ) and viscous (Gʺ) shear moduli of protein interfacial networks and to probe the effect of several nonionic surfactants at various concentrations. Time sweep protocols of buffered protein solutions yielded Gʹ

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Tailoring the Release of Drugs Using Excipientsent compliance. Polymeric excipients play a critical role in determining the mechanism and rate of drug release from the solid oral dosage forms. Regardless of the physicochemical properties of drug molecules and physiological conditions of the body, it is now possible to achieve site-specific deliv

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