Titlebook: Evolving Methods for Macromolecular Crystallography; The Structural Path Randy J. Read,Joel L. Sussman Conference proceedings 2007 Springe

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Familienunternehmen als Kategorienmarkeven search models the true crystal structure is the one for which the agreement between the observed and calculated structure factor amplitudes is maximised. This approach has been shown to be capable of successfully locating solutions even in cases as complex as a 23-dimensional, four-body search.

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Evolving Methods for Macromolecular CrystallographyThe Structural Path

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https://doi.org/10.1007/978-3-8350-5424-0 These approaches are intergrated with the MAIN model building and refinement tools, which also allow multicrystal averaging and refinement with non-crystallographic constraints across a variety of crystal forms.

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Cuno Pümpin,Günther Koseck,Christian Buttore than one third of the genes cloned, many proteins purified, and more than 100 structures determined. Some of these are for already-validated drug targets. Others have led to new functional understanding of important processes in the biology of the organism, providing validation of the structure-to-function paradigm.