Titlebook: Evolutionary Systems Biology; Orkun S. Soyer Book 20121st edition The Editor(s) (if applicable) and The Author(s), under exclusive license

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Metabolic Networks and Their Evolution, will discuss here two such changes, namely the elimination of reactions from a metabolic network through loss of function mutations in enzyme-coding genes, and the addition of metabolic reactions, for example through mechanisms such as horizontal gene transfer. Reaction addition also provides a win

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Evolutionary Characteristics of Bacterial Two-Component Systems,tors belonging to different TCSs in a species show high levels of similarity, which may facilitate crosstalk as well as the recruitment of components into new compound signalling systems. We furthermore find that bacterial lifestyle has an overriding influence on the presence and absence of TCS; whi

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Comparative Interaction Networks: Bridging Genotype to Phenotype,ns across complexes or pathways. Finally, we discuss how these evolutionary observations are being used to interpret cross-species chemical-genetic studies and how they might shape therapeutic strategies. Together, these interaction networks offer us an unprecedented level of detail into how genotyp

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Evolutionary Principles Underlying Structure and Response Dynamics of Cellular Networks,lular networks. We argue that this evolutionary framework could lead to deciphering evolutionary origin and relevance of proposed design principles, thereby allowing to predict their presence or absence in an organism based on its environment and biochemistry and their effect on its future evolution

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Genetic Redundancies and Their Evolutionary Maintenance,tions, but because of their actual benefits at present or in the recent past. The rest are probably preserved by selection on nonredundant pleiotropic functions. The studies summarized here illustrate the utility of systems analysis for understanding evolutionary phenomena and the importance of evol