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Titlebook: Essential Hypertension; Calcium Mechanisms a Kyuzo Aoki Book 1986 Springer-Verlag Tokyo 1986 hypertension.treatment

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Use of Isolated Membranes of Smooth Muscle to Study Calcium Channelsrmore, other studies show that binding of these antagonists correlates with their functional effects in the same tissue. However, the agents have no effect detected to date on Ca fluxes into or out of isolated vesicles from the same tissue. Thus, it is possible that Ca. channels are inactivated duri
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Therapeutic Role of Calcium Antagonists in Essential Hypertensionessential hypertension..A major, and as yet unresolved, question is whether a disturbance of calcium transport mechanisms in vascular smooth muscle represents a fundamental fault in essential hypertension. To demonstrate that this is the case, disturbances of calcium transport and an associated vasc
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Effects of Calcium Antagonists in Essential Hypertension with Special Reference to Renal Functionf the untreated blood pressure and the severity of the disease seem to be major determinants. Regional vascular resistance, age, renin status, and plasma concentrations obtained appear to be factors of limited value in this respect..In studies on renal function, nifedipine has been found to have sig
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Dihydropyridines As Antihypertensive Agents intracellular stores. Calcium entry blockers selectively and reversibly reduce the influx of Ca. into the cell through the cell membrane and from bound sites within the cell. The ability of Ca. channel blockers to relax vascular smooth muscle and, therefore, to decrease peripheral vascular resistan
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Altered Vascular Calcium Metabolism As a Possible Cause of Increased Blood Pressure in Essential Hypnot be excluded that the increased sensitivity is a substrate upon which other factors may act. Further work is required, particularly using human isolated vascular preparations, to delineate more precisely the role of vascular abnormalities in the pathogenesis of essential hypertension.
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Book 1986ctober 23 and 24, 1985 in Nagoya, Japan. The meeting was an official satellite symposium to the meeting of the Fifth International Symposium on Rats with Spon­ taneous Hypertension and Related Studies in Kyoto, October 20-22, 1985. The Nagoya symposium was made possible by offi­ cial grants from the
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Applications for Texture and Patterns,fspring. The rats with the highest blood pressure were selected from the offspring and brother-sister inbreeding provided rats with spontaneous hypertension. All the offspring of the third and successive generations developed hypertension. The development and establishment of a strain of SHR were completed by 1963.
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Modeling Sound Propagation in the Ocean,studies using an irreversible ligand of the dihydropyridine type for Ca channels applied to isolated cells found a similar locus of binding to plasma membranes, but binding characteristics were not studied. Thus, the relationship between binding of these antagonists to plasmalemmal sites and their functional effects needs further study.
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Discovery of the Spontaneously Hypertensive Ratfspring. The rats with the highest blood pressure were selected from the offspring and brother-sister inbreeding provided rats with spontaneous hypertension. All the offspring of the third and successive generations developed hypertension. The development and establishment of a strain of SHR were completed by 1963.
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