Titlebook: Essential Hypertension; Calcium Mechanisms a Kyuzo Aoki Book 1986 Springer-Verlag Tokyo 1986 hypertension.treatment

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Use of Isolated Membranes of Smooth Muscle to Study Calcium Channelsstudies using an irreversible ligand of the dihydropyridine type for Ca channels applied to isolated cells found a similar locus of binding to plasma membranes, but binding characteristics were not studied. Thus, the relationship between binding of these antagonists to plasmalemmal sites and their functional effects needs further study.

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Conservation Laws for Multiphase Flow,not be excluded that the increased sensitivity is a substrate upon which other factors may act. Further work is required, particularly using human isolated vascular preparations, to delineate more precisely the role of vascular abnormalities in the pathogenesis of essential hypertension.

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Etiological Classification of Hypertensione of crossbreedings of the spontaneously hypertensive rat (SHR), which demonstrated that the inheritance of hypertension in the SHR might be the incomplete dominant form transferred by three major genes and not completely polygenic. There are three qualitatively different kinds of hypertension anima

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Actions of Calcium Agonists and Antagonists on Femoral Arteries of Spontaneously Hypertensive Ratswas also observed in the SHR femoral artery. Contractions induced by alpha adrenoceptor stimulation were not different between SHR and WKY. Contractile responses of the SHR femoral artery to Bay k 8644 were antagonized competitively by both nifedipine (pA. = 8.36) and verapamil (pA. = 6.77), but non

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Calcium-Membrane Interactions in Smooth Muscle in Relation to Hypertensionelevated blood pressure in hypertension. It also occurs in several forms of experimentally induced hypertension in rats. Such a Ca-transport deficit is present in nonvascular smooth muscles as well in spontaneous hypertension, but not in experimental hypertension. This suggests that the altered ATP-

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Effects of Diltiazem on Myogenic Tone in Pressurized Brain Arteries from Spontaneously Hypertensive ntaneous tone is similar in resistance-sized cerebral arteries taken from hypertensive and normotensive rats; (2) tone is dependent on the influx of extracellular calcium; and (3) the diltiazem sensitivity of the population of calcium channels responsible for maintaining this tone is not altered in

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Calcium and Calcium Antagonists on Vascular Damage in Spontaneously and Dahl Hypertensive Ratsts (SHR SP), a high-salt diet resulted in severe lesions with high mortality without any additional increase in blood pressure. Treatment with the calcium antagonistic dihydropyridines nitrendipine or nimodipine markedly increased survival and the reduced vascular lesions without decreasing the high