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Titlebook: Erythropoietin and the Nervous System; Ahmet Höke (Associate Professor of Neurology and N Book 2006 Springer-Verlag US 2006 Nervous System

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Book 2006mulates red blood cell production, in recent years many laboratories have shown that EPO can act as a neuroprotective compound in a variety of injury paradigms in the nervous system. Past experience with relatively safety profile of this FDA-approved drug makes it an ideal candidate to take it into
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Expression of Erythropoietin and Its Receptor in the Central Nervous System, way to the bone marrow where it regulates red cell production by preventing apoptosis of erythroid progenitor cells. Recently, EPO has emerged as a multifunctional growth factor that plays a significant role in the nervous system. Both EPO and its receptor are expressed throughout the brain in glia
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Regulation of Erythropoietin Expression in the Nervous System: The Hypoxia Inducible Factor,) is a physiological response to hypoxia in oxygen-deprived tissues. Hypoxia-induced epo gene expression is regulated by the transcriptional activator hypoxia inducible factor (HIF). The epo gene contains a HIF binding site in its 3′ untranslated region, and its expression is upregulated concomitant
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Erythropoietin Neuroprotection in the Retina,ursors in the bone marrow. EPO and EPO receptor protein are also expressed by CNS neurons and glial cells. EPO exerts neuroprotective effects in various experimental in vitro and in vivo models of neural injury, such as mechanical trauma, neuroinflammation, and cerebral and retinal ischemia. In this
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