Titlebook: Endocrine FGFs and Klothos; Makoto Kuro-o Book 2012 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer S

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Type-1-Diabetes

The Structural Biology of the FGF19 Subfamily, subfamilies known for their paracrine functions during embryonic development. Compared to the members of paracrine FGF subfamiles, the three members of the FGF19 subfamily, namely FGF19, FGF21 and FGF23, have poor affinity for heparan sulfate (HS) and therefore can diffuse freely in the HS-rich ext

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,Klotho and βKlotho,estine upon feeding and acts on liver to suppress bile acid synthesis. FGF21 is secreted from liver upon fasting and acts on adipose tissue to promote lipolysis and responses to fasting. FGF23 is secreted from bone and acts on kidney to inhibit phosphate reabsorption and vitamin D synthesis. One cri

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