| 书目名称 | Endocrine FGFs and Klothos |
| 编辑 | Makoto Kuro-o |
| 视频video | |
| 概述 | Discusses potential of FGF23 and Klotho as novel diagnostic markers and therapeutic targets for chronic kidney disease.Gives an overview of current knowledge on FGF19 and FGF21.Comprehensive in scope |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors. |
| 出版日期 | Book 2012 |
| 关键词 | Endocrine; FGF; Fibroblast growth factor; Klotho; Kuro-o; gene expression |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4614-0887-1 |
| isbn_ebook | 978-1-4614-0887-1Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
发表于 2025-3-21 18:58:26
