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Titlebook: Emerging Strategies in Neuroprotection; Paul J. Marangos,Harbans Lal Book 1992 Birkh�user Boston 1992 Evolution.biology.brain.neuroscience

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Lazaroids: Novel Cerebroprotective Antioxidantstion in the acute pathophysiology of central nervous system (CNS) injury and ischemia (i.e., stroke) (Braughler and Hall, 1989; Hall and Braughler, 1989). The 21-aminosteroids, or “lazaroids,” are a novel series of compounds being developed for the acute treatment of traumatic or ischemic CNS injury
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Membrane-Derived Lipid Second Messengers as Targets for Neuroprotection: Platelet-Activating Factor in several human pathologies including asthma and shock, cardiac and systemic anaphylaxis, immune and renal disorders, and a variety of inflammatory conditions (Braquet et al., 1987; Prescott et al., 1990). In addition, several lines of evidence suggest the implication of PAF in various pathophysio
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Temperature Modulation of Neuronal Injurymental and clinical literature, on therapeutic hypo- and hyperthermia. The protective effect of profound hypothermia (30°C or less) has been well established during cardiac and intracranial surgical procedures necessitating interruption of blood flow to the brain. Hypothermia has also been and conti
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Clinical Trial Issues in Stroke Therapy(1990) stated that during this period we will see “The prevention of 80% of all strokes and protection of the brain during the acute stroke.” To accomplish this task new therapies must be developed. The safety and efficacy of any new agent must be demonstrated in adequate and well-controlled trials.
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Book 1992 as the decade of the brain, based largely on the rapid escalation of advances in the molecular neuro­ sciences and the likelihood that these will bear therapeutic fruit before the turn of the century. There is little doubt that the 1970s and 1980s have witnessed more remarkable advances in the mole
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