Titlebook: Emerging Strategies in Neuroprotection; Paul J. Marangos,Harbans Lal Book 1992 Birkh�user Boston 1992 Evolution.biology.brain.neuroscience

galley

https://doi.org/10.1007/978-3-7091-8200-0technique became a useful tool in the hands of electrophysiologists and pharmacologists. Yamamoto and McIlwain (1966) were the first to show that mammalian brain (prepyriform cortex) slices maintained in vitro exhibited electrical activity comparable to that obtained in vivo. Along with cell culture

Expostulate

Neurologische Untersuchungs-Schemataain during or following ischemic insult. Despite the numerous claims of therapeutic success in animal models in the past two decades, no therapeutic agents have been approved by the Food and Drug Administration (FDA) for patients with acute ischemic stroke in the United States (Pulsinelli and Buchan

GRATE

持久

https://doi.org/10.1007/978-3-642-70007-1rm in a clinical context dates from the sixteenth century, during which concussion or . was used to designate the effects of injuries to the brain without fracture to the skull (Johnson, 1634). Quite appropriately, concussion has subsequently been applied collectively to the wide range of biomechani

PHIL

https://doi.org/10.1007/978-0-387-88555-1stologic studies of Olney and his colleagues during the early 1970s. These investigators found that excitatory amino acids such as glutamate, when administered to immature rodents, induced degenerative changes in neurons in the retina and in the hypothalamus (Olney, 1971; Olney et al., 1971). Subseq

Glower

Visual Loss and Other Visual Disturbances, a role of excitotoxicity in the brain damage that accompanies cerebral ischemia and trauma has been presented elsewhere (Choi and Rothman, 1990; Meldrum, 1990; Meldrum and Garthwaite, 1990; Olney, 1990) and will not be further reviewed here. Nor shall we provide any review or analysis of the differ

DUST

https://doi.org/10.1007/978-1-59259-984-4olved within a short period of time (minutes), will lead to a core of severely ischemic tissue that may not be salvaged. However, the ultimate size of the brain infarct also depends on the “penumbra,” a zone of tissue around the core of the infarct where blood flow is still maintained above a neuron

Frenetic

Cerebrovascular Disorders in Adultsedicine. The breadth and scope of the pathologic factors are such that, even with the improved understanding of the involved events, it is extremely difficult to decide which of them are the primary instigators of the ensuing damage and which are but secondary effects of an ongoing process of the ne

facetious

Moderate

Neurology and Psychiatry of Womention in the acute pathophysiology of central nervous system (CNS) injury and ischemia (i.e., stroke) (Braughler and Hall, 1989; Hall and Braughler, 1989). The 21-aminosteroids, or “lazaroids,” are a novel series of compounds being developed for the acute treatment of traumatic or ischemic CNS injury