| 书目名称 | Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity | | 编辑 | Akihiko Yoshimura | | 视频video | | | 概述 | Addresses all aspects of the molecular and cellular biology of extracellular and intracellular immune checkpoint regulators.Promotes the understanding and application of extended immune checkpoint reg | | 丛书名称 | Current Topics in Microbiology and Immunology | | 图书封面 |  | | 描述 | .This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases...Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.. | | 出版日期 | Book 2017 | | 关键词 | Anti-tumor immune response; Tumor immune microenvironment; Regulatory T cells; PD-1; Autoimmune disease; | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-68929-6 | | isbn_softcover | 978-3-319-88684-8 | | isbn_ebook | 978-3-319-68929-6Series ISSN 0070-217X Series E-ISSN 2196-9965 | | issn_series | 0070-217X | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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发表于 2025-3-21 19:55:33
