Titlebook: Electrophysiological Analysis of Synaptic Transmission; Nicholas Graziane,Yan Dong Book 2016 Springer Science+Business Media New York 2016

Infinitesimal

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Measuring Presynaptic Release Probabilityream neurons and this process is mediated by presynaptic neurotransmitters and postsynaptic receptors. These neurotransmitters bind to postsynaptic receptors causing pore opening and ion influx/outflux. The flow of ions alters the postsynaptic membrane potential increasing or decreasing the likeliho

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armistice

Measuring Reversal Potentials change in direction can either mean inward currents becoming outward currents at a specific voltage or vice versa. Using reversal potential measurements allows the experimenter to determine ion specificity of a receptor/channel as well as the driving force of ions through the receptor/channel at a

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Amplitudeat a given time point. This chapter discusses amplitude measurements for in vitro slice electrophysiology and covers appropriate calculations for action potential amplitudes, field potential amplitudes, postsynaptic current/potential amplitudes, and steady-state current amplitudes. Like many electro

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Pre vs. Post synaptic Effectllowing a stimulus and how these alterations affect the firing properties of the innervated neuron. In this chapter we continue to discuss approaches that can be implemented to test presynaptic mechanisms of plasticity. In addition, we explain modifications that can occur in the postsynaptic cell af

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Run-Up and Run-Downe experimental recordings. Two such artifacts discussed in this chapter are current run-up and current run-down. Simply put, baseline responses increase (run-up) or decrease (run-down) over time. Membrane channels recorded using cell-attached, whole-cell, and excised-patch configurations are all sus

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Jill Petersen Adams,Margaret Thomas McGeheeysiological milieu. This chapter discusses external and internal solution components for in vitro brain slice electrophysiology. These recipes have been developed throughout the years to model the physiological environment and to help produce viable, healthy neurons.

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Salt Environmentysiological milieu. This chapter discusses external and internal solution components for in vitro brain slice electrophysiology. These recipes have been developed throughout the years to model the physiological environment and to help produce viable, healthy neurons.