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Titlebook: Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis; Otto R. Hommes,Giancarlo Comi Book 2004 Springer-Verlag Italia 20

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发表于 2025-3-21 19:04:04 | 显示全部楼层 |阅读模式
书目名称Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis
编辑Otto R. Hommes,Giancarlo Comi
视频video
概述Updates the reader on evolution in the MS field.New hypotheses and therapeutic options are presented
丛书名称Topics in Neuroscience
图书封面Titlebook: Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis;  Otto R. Hommes,Giancarlo Comi Book 2004 Springer-Verlag Italia 20
描述There is now evidence that irreversible brain damage accumulates very early in the course of multiple sclerosis. This book reviews the main neurobiological, magnetic resonance imaging, and clinical aspects of the early phases of the dis­ ease. Mechanisms ofirreversible axonal damage and the role played by the inter­ action of glia and the axon are highlighted. In contrast to what was believed for a long time, the sufficient availability of oligodendrocyte precursor cells to promote remyelination in acute lesions has now been demonstrated. For reasons not understood, this remyelination process fails or does not start, particularly in the chronic stages ofthe disease. These findings emphasize the importance of the "milieu" changes induced by an inflammatory process in limiting remyelination. However, first indications are that part of this inflammatory process may have a neuroprotective effect. Pathological studies in multiple sclerosis have now clearly demonstrated that destructive processes may be followed by recovery phases in such a way that myelin may be morphologically and functionally reconstituted. These findings provide the rationale for early treatment and emphasize the imp
出版日期Book 2004
关键词brain; magnetic resonance; magnetic resonance imaging; magnetic resonance imaging (MRI); neuropathology;
版次1
doihttps://doi.org/10.1007/978-88-470-2117-4
isbn_softcover978-88-470-2171-6
isbn_ebook978-88-470-2117-4
copyrightSpringer-Verlag Italia 2004
The information of publication is updating

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Genetic Regulation of Nerve Cell Death/Glial Activation and Protective Effects of Myelin Basic Proten 5% and 60% [7, 10, 11]. Notably, no single HLA type seems to exclude MS. It is therefore clear that as yet unidentified genes residing outside the HLA must also be of importance for disease susceptibility in MS.
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Monounsaturated Fatty Acids and Neuroprotection. The Results of a Study of Cognitive Decline in Oldmore-detailed procedure for the assessment of cognitive decline than those listed in the AAMI criteria. A high incidence (45%) of dementia was found in individuals aged >75 years who were diagnosed as having “minimal dementia” by the CAMDEX interview [7]. Furthermore, in another study 48% of patient
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Early Treatment in Multiple Sclerosis with Intravenous Immunoglobulin: Rationale and Study Design,ctive of this study was to investigate the efficacy of IVIg treatment, administered at 0.4 g/kg per day for 5 consecutive days, as a loading dose, and 0.4 g/kg per day every 6 weeks thereafter as a booster dose, for a 1-year period, on the risk of patients with clinically probable MS and positive br
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The Yin and Yang of Inflammation in Multiple Sclerosis,neity occurs is currently unknown. Are RR and PPMS different diseases or are they part of the same clinical spectrum? Why do some patients develop progressive disease whilst others do not? Answers to these questions will not only improve our understanding of MS, but will also have major implications
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Book 2004fect. Pathological studies in multiple sclerosis have now clearly demonstrated that destructive processes may be followed by recovery phases in such a way that myelin may be morphologically and functionally reconstituted. These findings provide the rationale for early treatment and emphasize the imp
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