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Titlebook: Drugs and Transport Processes; A Symposium B. A. Callingham Textbook 1973Latest edition Institute of Biology Endowment Trust Fund 1973 drug

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The relation between renal acidification and bicarbonate reabsorption. A view of CO2-mediated secret. To do this we must consider the chemistry of the hydration of carbon dioxide or of the hydroxylation of carbon dioxide, the properties of renal secretory cells, and the role of carbonic anhydrase in these processes.
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Current concepts of the mechanism of anion permeabilitysiderably grown and, for the first time, reasonably reliable experimental data on the penetration characteristics of rapidly permeating anion species such as chloride and the other halides has become available. The expansion of factual knowledge was accompanied by a critical reconsideration of exist
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Pore or carrier? Gramicidin A as a simple porethe ions or whether the structures which carry the sites are fixed in the membrane or free to move about. In order to answer these questions and more generally to establish the possible mechanisms for ion transport, it is useful to investigate model systems. Another reason for studying the propertie
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The use of lipid bilayers as cell membrane models: an experimental test using the ionophore, valinomf cell membranes. Although this similarity was originally discovered through interest in the mechanism of the action of the antibiotics in uncoupling oxidative phosphorylation, it has much wider implications for theories of membrane structure, suggesting that the lipid bilayer actually does provide
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Aqueous pores created in thin lipid membranes by the antibiotics nystatin, amphotericin B and gramicross the lipoidal plasma membrane through polar pores or channels.’ Recent work with model membranes has established that indeed unmodified lipid bilayers are so poorly permeable to polar non-electrolytes and especially to small ions that these species require parallel pathways . either carriers or
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D,kers, Bresler & Weinberger, 1960) and diuretic doses of mercury do not inactivate canine ATPase (Nechay, Palmer, Chinoy & Posey, 1967). At present it is possible only to challenge the hypothesis by posing additional requirements.
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