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Titlebook: Drugs Eicosanoids; Second Messengers. N John Fawcett Wilson Book 1995 Springer Science+Business Media Dordrecht 1995 Chloramphenicol.Methad

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Corporate Training Investment Decisionserable inter-individual variation in metabolism, plasma half-life varying from 8 to 51 hours. The therapeutic range in plasma for treatment of endogenous depression is 0.1-0.2 μg/ml (combined amitriptyline and nortriptyline concentration).
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Corporate Training Investment Decisionsalf-life of 2 to 10 hours. The exception is in neonates where the hepatic enzymes are underdeveloped and much caffeine is excreted unchanged. The half-life is 36 to 144 hours in neonates. Toxic effects are associated with plasma concentrations > 15 μg/ml and fatalities with >80 μg/ml.
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Economies as an Antitrust Defense Revisitedative and antimuscarinic effects but more pronounced extrapyramidal side-effects as compared with chlorpromazine. After oral administration, some 75% of the dose is excreted in urine with < 1% as unchanged drug and the remainder in the faeces. The half-life in plasma is 2 to 3 hours.
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Cyclosporin A,phrotoxicity which occurs in approximately a third of patients. The concentration difference between possible transplant rejection and toxicity is small. It has been suggested that whole blood measurements of 0.25-1 μg/ml or plasma concentrations of 0.05-0.2 μg/ml produce satisfactory immunosuppression and minimize adverse effects.
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Digoxin,s take 6 to 7 days to be achieved. Digoxin is excreted largely unchanged by the kidney hence clearance is prolonged by renal impairment. Therapeutic drug monitoring in hospitals has been shown to be cost-effective by reducing the incidence of side-effects and shortening in-patient stay.
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Acecainide (N-Acetylprocainamide),xcreted unchanged in urine. The half-life in plasma is 6-9 hours (procainamide 2.5-4 hours), increasing with renal impairment. Therapeutic concentrations in plasma have been proposed to be 10-30 μg/ ml for the sum of both procainamide and acecainide, or 4-10 μg/ml for procainamide and 6-20 μg/ml for acecainide.
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