Titlebook: Drugs Eicosanoids; Second Messengers. N John Fawcett Wilson Book 1995 Springer Science+Business Media Dordrecht 1995 Chloramphenicol.Methad

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Ethosuximide,t 20% of unchanged drug. The plasma half-life is 40 to 60 hours in adults and approximately 30 hours in children. There is good correlation between plasma concentration and response. The therapeutic range in plasma is 40-100 μg/ml.

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Etorphine,n morphine and its use carries some risk as it can be absorbed through human skin following accidental spillage. It is a drug of dependence but is said to produce less tolerance and respiratory depression than morphine.

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Sedative

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Alfentanil,ia. Prolonged use may lead to dependence. Biotransformation in the liver is to inactive metabolites which are excreted in urine. The half-life in plasma is about 1.5 hours. Plasma concentrations after a 50 μg/ kg intravenous dose have been measured as 0.54 μg/ml at 1 min falling to 0.038 μg/ml at 1 hour.

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Certainty

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