Titlebook: Drugs Affecting Lipid Metabolism; A. L. Catapano,A. M. Gotto (Chairman),Rodolfo Paol Book 1993 Springer Science+Business Media Dordrecht 1

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The Way They Were,The Way We Areso been clearly demonstrated that oxidative modification does occur . and that administration of some antioxidant compounds slows the progression of atherosclerosis in LDL receptor-deficient rabbits and in cholesterol-fed rabbits. Whether the antiathero-sclerotic effect of these compounds is limited

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The Way They Were,The Way We Are because it provides the opportunity for cholesteryl esters to be transferred from LDL and HDL into triglyceride-rich particles conferring on them atherogenic potential. Increased shunting of cholesteryl esters into triglyceride-rich lipoproteins appears to be related to impaired triglyceride metabo

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The Meaning of the Holocaust for Bioethicsh the liver and intestine. The gene responsible for this disease does not co-segregate with the apo a gene suggesting it is caused by the loss of some gene product. To gain an understanding of the apparently unique process necessary for apo a secretion, plasmids expressing apo a were transfected int

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The Way They Were,The Way We Areresult in a milder clinical phenotype. The clue to detection of these changes in the LPL gene might be to be to investigate patients who present with chylomicronemia when exposed to specific environmental stresseswhile continuing with only moderate hypertriglyceridemia in the resting state.

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The Way They Were,The Way We Areerchylomicronemia and recurrent episodes of acute pancreatitis..Analysis of the complete coding sequence, with intronic boundaries, and the promoter region of the LPL gene of the propositus revealed a G→C transversion at the 5’ donor splice site of intron 1. We suggest that this mutation is not comp

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The Way They Were,The Way We Areliver. High density lipoproteins (HDL) are the vehicle of cholesterol in this reverse transport, a function believed to explain the inverse correlation between plasma HDL levels and atherosclerosis. An attempt to stimulate, by the use of drugs, this transport process may hold promise in the preventi

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Multidimensional Wavelets and Applications the epidemiologic observation that HDL-cholesterol and apolipoprotein (apo) A-I are inversely correlated with the risk for coronary artery disease. More recent data indicate that HDL is involved in several other mechnisms such as coagulation, immunomodulation, cell proliferation, and detoxification