Titlebook: Drugs Affecting Lipid Metabolism; A. L. Catapano,A. M. Gotto (Chairman),Rodolfo Paol Book 1993 Springer Science+Business Media Dordrecht 1

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Structural Features that Determine the Functional Properties of the Loop Region of Human Lipoproteind site specific mutagenesis of lipoprotein lipase and hepatic lipase demonstrate an Asp-His-Ser catalytic triad covered by a peptide loop bounded by a conserved disulfide bridge. Substitution of the loop of lipoprotein lipase with either six or twenty-two residues of the hepatic lipase loop gives m

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Priapism

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Assault

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,The Expression and Regulation of Cholesterol 7α-Hydroxylase,liver cholesterol 7α-hydroxylase, obtained a specific antibody, cloned the cDNA and expressed an active enzyme in E. Coli. Using these reagents, we studied the regulation of 7α-hydroxylase by cholesterol, oxysterols, bile acids, hormones and other drugs. All results indicate that 7α-hydroxylase is r

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Cholesterol Metabolism in Normo and Genetically Hyperlipidemic Rats in Aging,train). Plasma and hepatic lipid levels and the activity of HMGCoA reductase, cholesterol 7α-hydroxylase were measured at the age of 2, 6 and 18 months. The effect of cholestyramine and simvastatin was also considered. Plasma cholesterol and triglyceride levels were higher in Yoshida and increased w

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The Way They Were,The Way We Ares on the mechanisms that may be involved in cell-catalyzed oxidation of LDL are reviewed and discussed. Finally, the pros and cons of undertaking clinical testing of the oxidative modification hypothesis are presented.

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Which Way Down the Slippery Slope?he rat 7α-hydroxylase gene was cloned and several liver specific and ubiquitous regulatory elements were found in the 5’-upstream sequence of the rat gene. Possible mechanisms of regulation of 7α-hydroxylase are proposed.