Titlebook: Drugs Affecting Leukotrienes and Other Eicosanoid Pathways; B. Samuelsson,F. Berti,G. P. Velo Book 1985 Plenum Press, New York 1985 Acetyl

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Prashant Sansgiry,Ioana Mihailae isolated and purified by RP-HPLC and SPHPLC. GC/MS analysis revealed that the three metabolites were: 8,15-dihydroxyeicosapentaenoic acid, 14,15-dihydroxyeicosapentaenoic acid and 15-hydroxyeicosapentaenoic acid. In addition, the non-enzymatic generation of an allylic hydroxy-epoxide metabolite (1

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Theory of Subband Decompositionhidonic acid (AA) was extensively converted to mono-HETEs and DHETEs in these cell types. These mono-HETEs and DHETEs were identified as oxidative products of AA via the 12- and 15-lipoxygenase pathways and DHETEs were exclusively generated from 15-lipoxygenase pathway. Incubation of AA or 12-L.-hyd

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Applied and Numerical Harmonic Analysisdroxy-eicosatetraenoic acids. The epoxygenase activity was found to be located predominantly in the renal cortex. This renal epoxygenase pathway also transformed PGI. to a new, previously unreported, metabolite. This metabolite was isolated and identified by radio gas chromatography and gas chromato

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Applied and Numerical Harmonic Analysisa return to a new sodium balance. This latter phenomenon, known as escape from the sodium-retaining effects of mineralocorticoids, is characterized by an increased urinary volume and sodium excretion. At the same time increased renal blood flow, glomerular filtration rate and reduced renal vascular

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Time-Frequency Analysis of Signalsumans with atherosclerosis (D’Angelo et al. 1978, Sinzinger et al. 1979) or with an exposure to risk factors (Silberbauer et al. 1979, Dadak et al. 1981) the generation of a prostacyclin-like activity is severely suppressed. On the other hand it has been recently reported that the urine excretion of

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https://doi.org/10.1007/978-1-4612-0113-7s., suggesting an important role for LTs in the allergic bronchoconstriction.. On the other hand anaphylactic shock is accompanied by increase in pulmonary vascular resistance. and both specific antigen-challenge and LTs “in vitro” induce a vasoconstriction of pulmonary vessels of different animal s

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Hypotheses, Questions, and Evidence,ortant areas in this development (1). The new knowledge has formed the basis for understanding the role of prostaglandins in many pathophysiological processes and for the therapeutic use of prostaglandins in various diseases.

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Sri Kurniawan,Andrew Arch,Sean-Ryan Smithrs, has been proposed as an important mediator of bronchoconstriction in man. These LTs display pronounced spasmogenic and vasoactive properties in various preparations and possess unprecedented potencies in respiratory smooth muscle in particular..

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Prashant Sansgiry,Ioana Mihaila of the antiaggregatory PG’s therefore could be of benefit in thrombotic situations, and can be done at different levels: selective in- hibition of platelet cyclooxygenase, stimulation of the PGI. synthesis, inhibition of TXA. synthesis or blockage of the TXA. receptor.

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Applied and Numerical Harmonic Analysis an increased urinary volume and sodium excretion. At the same time increased renal blood flow, glomerular filtration rate and reduced renal vascular resistance are observedl. Besides the haemodynamic factors, prostaglandins (PGs) and kallikreinkinin system have been suggested as being responsible, at least partly, for the escape phenomenon.