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Titlebook: Drugs Affecting Leukotrienes and Other Eicosanoid Pathways; B. Samuelsson,F. Berti,G. P. Velo Book 1985 Plenum Press, New York 1985 Acetyl

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Hypotheses, Questions, and Evidence,wo major complementary methods were selected by the scientists: gas-chromatography combined with mass spectrometry and radioimmunoassay (RIA) techniques. Both methods were improved throughout the years in regard of their specificity and sensitivity. The introduction of deuterated carriers for the fi
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Sri Kurniawan,Andrew Arch,Sean-Ryan Smiththe prostaglandin, the thromboxanes and the prostacyclins. These compounds are formed via the 5-Lipoxygenase pathway and play a major role as biolohical mediators on ommediate hypersensitivity reactions and inflammation ..
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Jane Seale,Sheryl Burgstahler,Björn Fisselertrating a broad range of activities. They all derive from some closely related polyunsaturated fatty acids, particularly arachidonic acid, which may be oxidized and further transformed in reactions initiated either by a fatty acid cyclooxygenase or, alternatively by a number of lipoxygenases. Prosta
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Franz Hlawatsch,Georg Tauböck,Teresa Twarochnction and vascular tone (see ref. 1 for a review) has prompted attempts to develop selective pharmacologic tools affecting their production with the aim of under standing their pathophysiologic role and possibly treating human disease states. Two different approaches have been followed; 1) differen
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Prashant Sansgiry,Ioana Mihaila and to some extent PGE. are proaggregatory, whereas prostacyciin (PGI.) and PGD. inhibi platelet activation. Attempts to change the balance in favour of the antiaggregatory PG’s therefore could be of benefit in thrombotic situations, and can be done at different levels: selective in- hibition of pl
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Prashant Sansgiry,Ioana Mihailalavonoids interact with many macromolecules in animal cells, change the activity of mammalian enzymes and influence permeability of cell membranes. Controlled trials on the therapeutical efficacy of flavonoids were relatively few, although flavonoids were consistently claimed to show anti-bleeding,
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