Titlebook: Drug Studies in the Elderly; Methodological Conce Neal R. Cutler (Director),Prem K. Narang (Supervis Book 1986 Plenum Publishing Corporatio

脊椎动物

L,on. These gaps in knowledge are the result of several factors, including slow development of analytical methodology for determination of benzodiazepine concentrations in body fluids for conduct of pharmacokinetic trials and lack of drug-sensitive measures to quantify benzodiazepine pharmacodynamics.

不满分子

L,ation for which the drug is intended and these patients are typically older, few studies have been conducted in which age alone was the influencing factor. Thus, much of the information presented is based on results of studies conducted in patients with arrhythmias or impaired function of another ma

Metamorphosis

N,gical doses needed for therapeutic benefit even for the same neuromuscular illness. Some patients can be managed with small doses of corticosteroids whereas others require much higher doses; in addition, others exhibit multiple severe complications whereas others have relatively little adverse effec

vitrectomy

坦白

Neal R. Cutler (Director),Prem K. Narang (Supervis

过于光泽

Methodological Concerns for Clinical Trials in Geriatricson. These gaps in knowledge are the result of several factors, including slow development of analytical methodology for determination of benzodiazepine concentrations in body fluids for conduct of pharmacokinetic trials and lack of drug-sensitive measures to quantify benzodiazepine pharmacodynamics.

Obligatory

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不可侵犯

故意

The Effects of Age on Hepatic Drug Metabolismnt pathological conditions, lifelong habits, and environmental exposure also contribute to the biological changes in the elderly. As a result, there are wide differences in the rates of deterioration of organs and enzyme systems with age. Therefore, chronological aging may not necessarily be a true reflection of physiological aging.