Titlebook: Drug Studies in the Elderly; Methodological Conce Neal R. Cutler (Director),Prem K. Narang (Supervis Book 1986 Plenum Publishing Corporatio

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G,ictated by demographic changes. As can be seen from Fig. 1, based on current projections, the present U.S. population of older people (those 65 years of age and over) will have more than doubled by the year 2030.. It is expected that over 50 million people will belong to this group and will constitu

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H, It may be reasonable to relate the increasing incidence of infection or cancer to immune senescence. The precise contribution of changing immune competence to other diseases of aging such as Alzheimer’s disease, atherosclerosis, and diabetes must be considered speculative. However, extensive basic

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I,ears and is followed by a gradual, often linear decline.. Many physiological and biochemical changes occur with “normal” aging. In addition, concomitant pathological conditions, lifelong habits, and environmental exposure also contribute to the biological changes in the elderly. As a result, there a

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L,have been correlated with therapeutic effects. It is thus important to understand the influence of various factors such as age, disease states, and concurrent therapy on the drug’s kinetics, as these factors often alter drug pharmacokinetics (and therefore therapeutic efficacy) and are present in a