Titlebook: Drug Resistance in Leukemia and Lymphoma III; G. J. L. Kaspers,R. Pieters,A. J. P. Veerman Book 1999 The Editor(s) (if applicable) and The

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https://doi.org/10.1007/978-3-322-85040-9 to patients with low MRP expression. MRP does not predict for response to induction chemotherapy but intermediate or high MRP expression might be associated with shorter overall survival of the patients.

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https://doi.org/10.1007/978-3-322-85040-9odulatory effect of CsA on calcein-AM uptake (r=0.83, p<0.0001). Pgp activity was higher in CD34+ leukemia than in CD34- leukemia (2.26±1.50 vs 1.46±1.21 respectively, p=0.003) and MRP1 activity was higher in CD34- leukemia than in CD34+ leukemia (1.77±0.40 vs 1.4±0.29 respectively, p=0.004). Pgp ex

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0065-2598 ic, such as for glucocorticoids and antifolates. Much in­ formation is provided on apoptosis and its regulators, and on the results of cell culture drug resista978-1-4613-7180-9978-1-4615-4811-9Series ISSN 0065-2598 Series E-ISSN 2214-8019

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Clinical Significance of P-Glycoprotein (P-gp) Expression in Childhood Acute Lymphoblastic Leukemian the P-gp positive group was significantly worse (Logrank P=0.009) than in the P-gp negative patients. In the relapsed patient population 10/12 P-gp positive cases experienced an unfavourable outcome compared with 10/22 P-gp negative patients [Risk Ratio 2.21 (0.90–5.45)]. .: P-glycoprotein express

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Comparison of P-Glycoprotein Expression and Function with , Sensitivity to Anthracyclines in AMLify individual patients whose cells exhibited P-gp expression and function teamed with . resistance to, and modification of, the anthracyclines. Furthermore, it is possible to identify which modulator had the greatest effect. The fact that we obtained higher indications of resistance reversal using

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Quinine Improves Results of Intensive Chemotherapy (IC) in Myelodysplastic Syndromes (MDS) Expressin 8 months in patients treated with chemotherapy alone (p=0.01). In PGP negative patients, median KM survival was 14 months in patients allocated to the quinine group, and 14 months in patients treated with chemotherapy alone. Side effects of quinine mainly included vertigo and tinnitus that generall