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Titlebook: Drug Resistance in Leukemia and Lymphoma III; G. J. L. Kaspers,R. Pieters,A. J. P. Veerman Book 1999 The Editor(s) (if applicable) and The

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https://doi.org/10.1007/978-3-322-85040-9ence (NF), is related to cell compounds, i.e. proteins (1), nicotinic coenzymes (2), flavins (3), etc., engaged in structural and metabolic processes. Thus a correlation does exist between NF emission and morpho-functional state of cells.
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https://doi.org/10.1007/978-3-322-85040-9ree-Wilson analysis and a combined Hansch/Free-Wilson analysis on a set of 48 compounds using artificial neural networks (ANN). In comparison to classical multiple linear regression (MLR) analysis, the ANN showed equal or even slightly better predictive power in leave one out cross validation proced
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https://doi.org/10.1007/978-3-322-85040-9(P-gp) expression and function by flow cytometry. P-gp antigen expression was determined with the monoclonal antibodies 4E3 and MRK16. Transport function was assessed by measuring the modulating effect of verapamil on the intracellular retention of Rhodamine 123..P-gp positivity at relapse was not s
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https://doi.org/10.1007/978-3-322-85040-9e Pgp and MRP1 functions, respectively. There was a good correlation between MRP1 expression and the modulatory effect of probenecid (a specific modulator of MRP1) on the calcein efflux (r=0.91, p=0.0003) and between Pgp expression and the modulatory effect of CsA on calcein-AM uptake (r=0.96, p<0.0
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https://doi.org/10.1007/978-3-322-85040-9transcript levels of the chemoresistance genes mdr-1 and MRP, and the proto-oncogene bcl-2, by validated contamination-protected quantitative RT-PCR. In newly diagnosed AML mainly tumors of the granulocytic lineage (FAB M1-M2) expressed increased mdr-1 mRNA amounts. The MRP gene was expressed in all
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