Titlebook: Drug Resistance in Leukemia and Lymphoma III; G. J. L. Kaspers,R. Pieters,A. J. P. Veerman Book 1999 The Editor(s) (if applicable) and The

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Principles of Medical Treatmentphenotyping, hemogram, remission and outcome have been examined. We have measured the initial diagnosis, remission and relapse levels of P-gp by binding a specific monoclonal antibody (UIC2) and functional properties of the drug resistance with flow cytometry in childhood ALL and AML.

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https://doi.org/10.1007/978-3-642-83312-0ify individual patients whose cells exhibited P-gp expression and function teamed with . resistance to, and modification of, the anthracyclines. Furthermore, it is possible to identify which modulator had the greatest effect. The fact that we obtained higher indications of resistance reversal using

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Yeasts in Pregnancy and Neonatal Mycoses, 8 months in patients treated with chemotherapy alone (p=0.01). In PGP negative patients, median KM survival was 14 months in patients allocated to the quinine group, and 14 months in patients treated with chemotherapy alone. Side effects of quinine mainly included vertigo and tinnitus that generall

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Genital Colonization in the Female Sex,nfusion at a rate of 10 mg/kg/24h for 5 or 6 days, depending on the duration of chemotherapy. In both studies a loading dose of 2 mg/kg of PSC 833 was given on day 1. In the 5-day regimen, the final study doses of the cytotoxic agents were C 1 g/m./d, M 4.0 mg/m./d, and E 40 mg/m./d. In the 6-day re

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Vygotsky and Informal Science Learning ICC. Results of Pgp expression were consistent on FCM and ICC in 23 of the 28 (82%) samples tested. Overall, Pgp expression was observed by ICC or FCM in 23 (67%) patients, including 11 (58%) newly diagnosed patients and 12 (80%) patients in relapse. Functional Rh123 efflux (Rh123+) was observed in

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https://doi.org/10.1007/978-1-4899-2614-25a patient which is the first report of MDR-3 Pgp expression being detected in AML; suggesting that MDR-3 Pgp expression may be limited to particular subtypes of this disease..Results from B-NHL cases were inconclusive with varying expression of MDR-1 and MDR-3 Pgps observed. Work is currently under

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Väter, Männer und kindliche Entwicklung Sequence analysis revealed that all patients were heterozygous for a point mutation in the promoter (T-C transition at +8). Four normals (4%) were found to be heterozygous for the mutation. Confirmation of the mutation was performed by oligonucleotide probe hybridization. All but two of the AML pat

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https://doi.org/10.1007/978-3-322-85040-947 (57%) samples had both low dnr accumulation and at least one positive confirmatory test (a modulated functional assay and/or protein overexpression) and were categorised as “confirmed MDR”. 15/47 patients (32%) were MDR negative in all 4 assays. 5/47 (11%) patients had unconfirmed low dnr accumul

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https://doi.org/10.1007/978-3-322-85040-9 were functionally inactive. In 10/12 and 13/15 samples however, an efflux pump was active and dependent of verapamil, but without detectable antigen. The functional flow cytometric assay allows evaluation of non-P-gp efflux pumps and, therefore, is more clinically relevant since it may better ident

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https://doi.org/10.1007/978-3-322-85040-9negative patients but only 8 months for LRP-positive patients (p = 0.006). Disease-free survival was 9 months for LRP-negative patients and 6 months for LRP-positive patients (p = 0.078). Thus LRP predicts for poor outcome indicating that the LRP gene is a clinically relevant drug resistance gene in